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KMID : 0370019870010000030
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Chung-Ang Journal of Pharmacal Sciences
1987 Volume.1 No. 0 p.30 ~ p.39
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A Study on the Low-Energy Emulsification in the Manufacturing Procedure of Nonionic Oil-in-water Type Cream
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차돈규/Cha Don Kue
이광표/Lee Kwang Pyo
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Abstract
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Low-Energy Emulification, an emulsification technique proposed by Lin to cut down mechanical and tehrmal energies in the process of emulsions, was examined in terms of emulsion quality and compared with the similar emulsion made with a conventional hot process. Experimental data obtained from skin care formulation consisting of oil-in-water emulsion stabilized with the nonionic surfactant indicate that the technique is extremely flexible and is capable of producing emulsions with varying droplet sizes. The key to success in applying the techniqe lies in understanding and controlling the physical variables responsible for causing a droplet size variation. The key variables found to produce physicochemically stable emulsions were: first stage emulsification temperature, mixing intensity, ratio of external phase added during the first stage of emulsification to that of second stage dilution, rate and the mode of phase combination. By effectively controlling these variables, it has been demonstrated that it is possible to produce emulsion with smaller and more uniform droplet size distribution using the low-energy technique than similar emulsion obtained with the conventional hot emulsification. Holding a large amount of external phase for the addition of α phase to the concentrate resulted in a substantial reduction of not only thermal and mechanical energies but also processing time.
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